FOSHAN PHARMA CO., LTD.
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Levamisole Hydrochloride/CAS:16595-80-5 Levamisole hydrochloride Alias: (S) -6- phenyl -2,3,5,6- four - 1H imidazo [2,1-B] thiazole mono hydrochloride; L-2,3,5,6- four hydrogen -6- phenyl imidazole [2,1-6] thiazole hydrochloride; levamisole hydrochloride; left-handed four imidazole; (S) - (-) -6- phenyl -2,3,5,6- four hydrogen imidazo [2,1-b] thiazole hydrochloride; levamisole hydrochloride; L-2,3,5,6 four hydrogen -6- phenyl imidazo (2,1-B) thiazole hydrochloride; levamisole hydrochloride four imidazole English Name: Levamisole Hydrochloride CAS:16595-80-5 EINECS:240-654-6 Molecular formula: C11H12N2S - ClH Molecular weight: 240.757 Function: This product is four imidazole left body, activity of about four imidazole (racemic) 1 ~ 2 times, but the side effects is low. And microtubule structure of the worms may have inhibitory effect. Levamisole and immune regulation and immune excitation function. Has good effect on Ascaris, hookworm, pinworm and strongyloidiasis. Properties: white to pale yellow crystalline powder, odorless, bitter taste. Temperature 227-229 degrees. Soluble in water, methanol, ethanol and glycerol, slightly soluble in chloroform, insoluble in acetone, ether. Then the acidic condition is stable, easy to decompose failure under alkaline conditions. Production method: by racemic four imidazole (C11H12N2S, [5036-02-2]) separation, analysis, salt and alkali. The BIS formyl -D- tartaric anhydride with boiling water, hydrolysis of 40min. Cooling to 45 DEG C, using sodium hydroxide solution to adjusting the pH to 7.5, adding the racemic four imidazole. Thermal insulation for half an hour after cooling to 10 Deg. C, filtering, water washing, to levamisole on benzoyl tartrate. The pH adjusted to 9 with sodium hydroxide solution, filtering, water washing to levamisole. PH to 3-4 with hydrochloric acid, adding activated carbon decolorization, filtration, the filtrate was concentrated to dry, and acetone cooled to 0 DEG C. Precipitation crystallization. Dry filter, levamisole hydrochloride. Separation of benzoyl tartaric acid levamisole salt, mixed liquid obtained mother liquid as levamisole free alkali, obtain the racemization of racemic four imidazole. Racemic four imidazole can also adopt the split n-p-tolysulfonyl-l-glutamic acid or camphor sulfonic acid. Standard: BP/USP Packing: 25KG board barrel |
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Product Tags: Levamisole Hydrochloride 16595-80-5 |
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